Storage-stable dust-free homogeneous particulate formulation

US9789063B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Felicitas Guth · Neustadt, DE
• Karl Kolter · Ludwigshafen am Rhein, DE
• Michael Schönherr · Bischofswerda, DE
• Michael Muller · Munich, DE

Key dates

• Filing date: Sep 25, 2013
• Grant date: Oct 17, 2017
• Expiry date: Sep 25, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described is a storage-stable dust-free homogeneous particulate formulation. The formulation consists of (a) at least one water-soluble Vitamin E-derivative, (b) at least one hydrophilic polymer, (c) optionally additional surface-active substances, and (d) optionally additional pharmaceutical additives. The sum of (a), (b), (c) and (d) equals 100% by weight of the formulation. The fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Describe also is a process for manufacturing the formulation, and use of the formulation as a solubilizing composition in pharmaceutical formulations.