Inhibition of hypoxia-inducible factor activity with Carica papaya extracts

US9789144B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• Universiti Putra Malaysia · MY

Inventors

• Eric J. Stanbridge · Newport Beach, US
• Norazizah Shafee · Kapar, MY
• Khatijah Yusoff · Kapar, MY

Key dates

• Filing date: Mar 13, 2014
• Grant date: Oct 17, 2017
• Expiry date: Nov 3, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2236/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An extract of Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed is used as an inhibitor of HIF to effectively block hypoxia-inducible factor (HIF) function and methods of use thereof. More specifically it relates to the use of the Carica papaya plant extract to eliminate unwanted cells by inhibiting HIF in the prevention and treatment of hypoxia-related conditions and diseases such as inflammatory diseases, vascular diseases, cancer and infectious diseases. In a particular embodiment, a solid hypoxic tumor in a patient is treated by administering to the patient a therapeutically acceptable amount of an extract of Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed, preferably an alcohol extract such as a methanol extract, whereby to inhibit hypoxia-inducible factors in the tumor.