Methods for treating back or neck pain caused by NGF using a therapeutic agent consisting of ReN-1820, ALE-0540 and capsaicin

US9789161B2 · kind B2 · utility

Assignee

• Warsaw Orthopedic, Inc.

Inventors

• Josee Roy · Memphis, US
• Susan J. Drapeau · Cordova, US
• Jeffrey C. Marx · Germantown, US

Key dates

• Filing date: Apr 28, 2006
• Grant date: Oct 17, 2017
• Expiry date: Sep 9, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y304/24069
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.