DNA sequence, and recombinant preparation of the grass pollen allergen Lol p 4

US9789178B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Andreas Nandy · Hamburg, DE
• Helmut Fiebig · Schwarzenbek, DE
• Oliver Cromwell · Bad Nenndorf, DE

Key dates

• Filing date: Nov 7, 2014
• Grant date: Oct 17, 2017
• Expiry date: Nov 7, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilized for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.