RNAi vitamin D conjugates

US9789197B2 · kind B2 · utility

Assignee

• Extend Biosciences, Inc. · US

Inventors

• Tarik Soliman · Chester Springs, US
• Laura M. Hales · Cambridge, US
• Daniel B. Hall · Easton, US
• Howard Sard · Arlington, US
• Vishnumurthy Hegde · Chelmsford, US

Key dates

• Filing date: Oct 21, 2015
• Grant date: Oct 17, 2017
• Expiry date: Oct 21, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides non-hormonal vitamin D conjugated to therapeutic RNA compounds that result in the compounds having increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. The vitamin D targeting groups are coupled to the therapeutic RNA compounds via the third carbon on the vitamin D backbone.