Heteroatom containing deoxyuridine triphosphatase inhibitors
US9790214B2 · kind B2 · utility
19Cited by
6References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 2, 2015 |
| Grant date | Oct 17, 2017 |
| Priority date | — |
| Expiry date | Jan 2, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions in a method of treating cancer. The dUTPase inhibitors disclosed contain a uracil isostere in the molecule represented by a 2,6-diketopiperazine moiety. Thioanalogs of the uracil isostere where a thione replaces each of the ketone are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.