Established human brown adipocyte line and method for differentiation from an hMADS cell line
US9790469B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jun 23, 2009 |
| Grant date | Oct 17, 2017 |
| Priority date | — |
| Expiry date | Mar 19, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/81
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The subject matter of the invention is a functional population of human brown adipocytes, in which the expression of UCP1, CIDEA, CPT1B and Bc12 is higher, the expression of Bax is lower and the expression of PPAR-alpha, PGC-1alpha, PGC-1 beta and PRDM16 is similar compared with the corresponding expressions of a population of human white adipocytes. The invention also relates to a method for differentiation of hMADS cells into the functional population of human brown adipocytes, to a method for conversion of a population of human white adipocytes into the functional population of human brown adipocytes, and also to a method of screening for molecules capable of modulating the bodyweight in an individual.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.