Antisense antibacterial compounds and methods

US9790495B2 · kind B2 · utility

Assignees

• Oregon State University · US
• The Board of Regents of the University of Texas System · US

Inventors

• Bruce L. Geller · Corvallis, US
• David Greenberg · Omer, IL

Key dates

• Filing date: May 15, 2015
• Grant date: Oct 17, 2017
• Expiry date: May 15, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are antisense morpholino oligomers targeted against bacterial virulence factors such as genes that contribute to antibiotic resistance or biofilm formation, or genes associated with fatty acid biosynthesis, and related compositions and methods of using the oligomers and compositions, for instance, in the treatment of an infected mammalian subject.