Signature for the diagnosis of lung cancer aggressiveness and genetic instability
US9790556B2 · kind B2 · utility
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Key dates
| Filing date | Jan 7, 2013 |
| Grant date | Oct 17, 2017 |
| Priority date | — |
| Expiry date | Jan 18, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for diagnosing aggressiveness of a lung cancer in a patient from a lung cancer sample of the patient, comprising: a) detecting in vitro an expression profile of the DNA replication stress signature, the signature comprising the CDC6, CLASPIN, PLK1, and POLQ genes, as well as, optionally, RAD51; b) comparing the the expression profile to a reference expression profile, and d) diagnosing cancer aggressiveness from the comparison. Dedicated microarrays and kits are also described, as well as a method of selecting or adapting a suitable treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.