Multi-organ chip with improved life time and homoeostasis

US9791433B2 · kind B2 · utility

Assignee

• TissUse GmbH · DE

Inventor

• Uwe Marx · Postbauer-Heng, DE

Key dates

• Filing date: Aug 15, 2013
• Grant date: Oct 17, 2017
• Expiry date: Feb 1, 2034

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/082
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention is directed to a multi-organ-chip device comprising a base layer; an organ layer arranged on the base layer; an antra layer arranged on the organ layer; and an actuator layer; wherein the base layer is configured to provide a solid support for the further layers; the organ layer is configured to comprise a multiplicity of individual organ equivalents, each organ equivalent comprising one or more organ growth sections, each of the organ growth sections being configured to comprise an organoid cavity for housing at least one organoid of an organ and to comprise a micro-inlet and a micro-outlet for fluid communication between the organoid cavity of the organ growth section and a self-contained circulation system, wherein the organ layer comprises at least one organ equivalent configured to represent the organs lung, small intestine, spleen, pancreas, liver, kidney and bone marrow, respectively, and a self-contained circulation system configured to be in direct fluid communication with the organ growth sections of the organ layer via the micro inlets and outlets of the organ growth sections; the antra layer is configured to comprise a multiplicity of cavities and …