Receptor binding ligands, their use in the detection of cells with biological interest
US9791435B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 8, 2010 |
| Grant date | Oct 17, 2017 |
| Priority date | — |
| Expiry date | Oct 21, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2400/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for the identification and quantification of the expression of membrane receptors present on the surface of target cells using at least two soluble receptor binding ligands derived from the soluble part of the glycoprotein of an enveloped virus that interacts with a cellular cognate receptor, the receptor binding ligand containing a part or the totality of one of the receptor binding domains (RBD) of the glycoprotein, and the soluble receptor binding ligand being liable to interact with the at least one membrane receptor of a target cell, for the identification and quantification of the expression of membrane receptors present on the surface of target cells, the identification and quantification taking place at a given time or during a given time interval, and allowing the determination of a physiological state of the target cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.