Method for prevention of colectomy

US9795627B2 · kind B2 · utility

Assignee

• Index Pharmaceuticals AB · SE

Inventors

• Charlotte Admyre · Handen, SE
• Arezou Zargari · Solna, SE
• Oliver Von Stein · Upplands Väsby, SE
• Petra Von Stein · Spånga, SE

Key dates

• Filing date: Sep 14, 2016
• Grant date: Oct 24, 2017
• Expiry date: Sep 14, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/31
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treating chronic active ulcerative colitis in a subject that is refractory or responds insufficiently or is intolerant to anti-inflammatory therapy, comprises administering to a patient in need thereof an effective exposure of an oligonucleotide comprising the sequence 5′-GGAACAGTTCGTCCATGGC-3′ (SEQ ID NO.2), wherein at least one CG dinucleotide is unmethylated. The oligonucleotide is not administered with corticosteroids or glucocorticosteroids.