Tetrasubstituted alkene compounds and their use

US9796683B2 · kind B2 · utility

Assignee

• Eisai R&D Management Co., Ltd. · JP

Inventors

• Mark G. Bock · Hatfield, US
• Ming-Hong Hao · Chesterfield, US
• Manav Korpal · Winchester, US
• Vijay Kumar Nyavanandi · Hyderabad, IN
• Xiaoling Puyang · Cambridge, US
• Susanta Samajdar · Savanuru, IN
• Peter Smith · Arlington, US
• John Wang · Andover, US
• Guo Zhu Zheng · Lexington, US
• Ping Zhu · Boxborough, US

Key dates

• Filing date: May 27, 2016
• Grant date: Oct 24, 2017
• Expiry date: May 27, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.