Inhibitors of Jun N-terminal kinase

US9796706B2 · kind B2 · utility

Assignee

• IMAGO PHARMACEUTICALS, INC. · US

Inventors

• Hing L. Sham · South San Francisco, US
• Roy Hom · San Francisco, US
• Andrei W. Konradi · Burlingame, US
• Gary Probst · San Francisco, US
• Simeon Bowers · Oakland, US
• Anh Truong · Burlingame, US
• R. Jeffrey Neitz · San Francisco, US
• Jennifer Sealy · Oakland, US
• Gergely TOTH · Palo Alto, US

Key dates

• Filing date: Dec 27, 2016
• Grant date: Oct 24, 2017
• Expiry date: Dec 27, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula:or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.