Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and method of use
US9796711B2 · kind B2 · utility
0Cited by
1References
42Claims
0Family size
Assignees
Inventors
- Rhalid Akkari
- Luke Jonathan Alvey
- Xavier Marie Bock
- Pieter Isabelle Roger Claes
- Marlon D. Cowart
- Elsa De Lemos
- Nicolas Desroy
- Béranger Duthion
- Gregory A. Gfesser
- Romain Luc Marie Gosmini
- Christopher Gaëtan Housseman
- Koen Karel Jansen
- Jianguo Ji
- Philip R. Kym
- Jean-Michel Lefrancois
- Oscar Mammoliti
- Christel Jeanne Marie Menet
- Gregory John Robert Newsome
- Adeline Marie Elise Palisse
- Sachin V. Patel
- Mathieu Rafaël Pizzonero
- Anurupa Shrestha
- Elizabeth C. Swift
- Steven Emiel Van der Plas
- Xueqing Wang
Key dates
| Filing date | Oct 7, 2016 |
| Grant date | Oct 24, 2017 |
| Priority date | — |
| Expiry date | Oct 7, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides for compounds of formula (I)wherein R1, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.