Tricyclic heterocycles as anticancer agents
US9796717B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Feb 19, 2014 |
| Grant date | Oct 24, 2017 |
| Priority date | — |
| Expiry date | Feb 19, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tricyclic chemical modulators of FOXO transcription factor proteins are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity, stress-induced depression, inflammation, and acne. The compounds are of the following and similar genera:in which Het is an aromatic heterocyclic ring and Y is a point of attachment of various side chains and rings. An example of such a compound is 4-chloro-N-(3-(10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepin-5-yl)propyl)benzenesulfonamide:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.