Pyridopyrimidine or pyrimidopyrimidine compound, prepration method, pharmaceutical composition, and use thereof

US9796732B2 · kind B2 · utility

Assignee

• SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD. · CN

Inventors

• Jingkang Shen · Shanghai, CN
• Ke Yu · Alpharetta, US
• Tao Meng · North Plainfield, US
• Lanping Ma · Shanghai, CN
• Arie Zask · New York, US
• Lanfang Meng · Shanghai, CN
• Xin Wang · Shanghai, CN
• Yiyi Chen · Changzhou City, CN

Key dates

• Filing date: Sep 1, 2015
• Grant date: Oct 24, 2017
• Expiry date: Sep 1, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention belongs to the field of pharmaceutical Chemistry. In particular, the present invention relates to a pyridopyrimidine or pyrimidopyrimidine compound as represented by general formula (I), or an isomer thereof or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof, a preparation method, a pharmaceutical composition and uses thereof in preparing a mTOR inhibitor. As a mTOR inhibitor, the compound or the pharmaceutical composition thereof can be used for treating a disease or condition due to PI3K-AKT-mTOR signalling pathway malfunction.