Oligonucleotide modulators of the toll-like receptor pathway

US9796979B2 · kind B2 · utility

Assignee

• QUARK PHARMACEUTICALS, INC. · US

Inventors

• Elena Feinstein · Rehovot, IL
• Svetlana Adamsky · Gdera, IL
• Sharon Avkin-Nachum · Nes Ziona, IL
• Hagar Kalinski · Nesher, IL
• Igor Mett · Rehovot, IL

Key dates

• Filing date: Jul 28, 2016
• Grant date: Oct 24, 2017
• Expiry date: Jul 28, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/51
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed herein are double stranded nucleic acid molecules and pharmaceutical compositions comprising same useful in the treatment of, inter alia, acute and chronic inflammation, neuropathic pain, primary graft dysfunction (PGD) after lung transplantation in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA compounds, which down regulate or inhibit expression of Toll like receptor 4.