Method for storage and stabilization of a target substance

US9797871B2 · kind B2 · utility

Assignee

• GE Healthcare Bio-Science AB · US

Inventors

• James Van Alstine · Stockholm, SE
• Johan Ohman · Uppsala, SE
• Philippe Busson · Nantes, FR
• Ronnie Palmgren · Uppsala, SE
• Klas Allmer · Täby, SE
• John Daicic · Uppsala, SE

Key dates

• Filing date: Apr 28, 2011
• Grant date: Oct 24, 2017
• Expiry date: Jun 2, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2030/562
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to a system and method for the stable storage of sensitive biological or chemical target substance, in a bound form on certain capture media. The method comprised providing a sample containing the target substance in a suitable buffer; combining the sample with a capture media to effect reversible binding of the target substance to the capture media; and storing the capture media with the target substance at between about −20 and 20° C.; and recovering the target substance from the capture media. The target substance recovered maintains the desired activity. Also provides are methods for reducing aggregates in the sensitive biological or chemical target substance.