Method of screening for a compound for inhibitory activity of FN14-tweak interaction
US9797882B2 · kind B2 · utility
11Cited by
1References
11Claims
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Key dates
| Filing date | Jul 9, 2014 |
| Grant date | Oct 24, 2017 |
| Priority date | — |
| Expiry date | Jul 9, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.