Pharmaceutical core-shell composite powder and processes for making the same

US9801820B2 · kind B2 · utility

Assignee

• New Jersey Institute of Technology · US

Inventors

• Daniel To · North Wales, US
• Rajesh Dave · Short Hills, US
• Catharina Knieke · Ludwigshafen, DE
• Ecevit Bilgili · Woodbridge, US
• Mohammed A. Azad · Harrison, US

Key dates

• Filing date: Nov 8, 2013
• Grant date: Oct 31, 2017
• Expiry date: Jun 28, 2034

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B05D1/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.