Pyridinyl and fused pyridinyl triazolone derivatives

US9801872B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• John David Lawson · San Diego, US
• Mark Sabat · Loveland, US
• Nicholas Scorah · San Diego, US
• Christopher Ronald Smith · San Diego, US
• Phong Vu · San Diego, US
• Haixia Wang · San Diego, US

Key dates

• Filing date: Jun 29, 2016
• Grant date: Oct 31, 2017
• Expiry date: Jun 29, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula 1,or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.