Compositions and methods of treating cancer

US9801922B2 · kind B2 · utility

Assignees

• University of Iowa Research Foundation · US
• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Douglas R. Spitz · Iowa City, US
• Michael K. Schultz · Iowa City, US
• Kyle Kloepping · Iowa City, US
• Yueming Zhu · Iowa City, US
• Nukhet Aykin-Burns · Little Rock, US
• Max S. Wicha · Ann Arbor, US

Key dates

• Filing date: Aug 2, 2012
• Grant date: Oct 31, 2017
• Expiry date: Jun 22, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria (“an XTPP agent”) or a pharmaceutically acceptable salt thereof, an inhibitor of hydroperoxide metabolism and a pharmaceutically acceptable diluent or carrier.