Lipocationic polymers and uses thereof

US9801944B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Daniel J. SIEGWART · Dallas, US
• Jing HAO · Tuji, CN
• Kejin ZHOU · Dallas, US
• Jason Miller · Dallas, US
• Petra Kos · Dallas, US
• Lian Xue · Dallas, US

Key dates

• Filing date: Sep 9, 2016
• Grant date: Oct 31, 2017
• Expiry date: Sep 9, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.