Synthetic polyurethane composite

US9801946B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• Scott A. Guelcher · Spring Hill, US
• Jerald E. Dumas · Atlanta, US
• Edna Margarita Prieto · Nashville, US
• Anne Talley · Nashville, US
• Andrew Harmata · Nashville, US
• Katarzyna Jadwiga Zienkiewicz · Nashville, US

Key dates

• Filing date: Apr 22, 2013
• Grant date: Oct 31, 2017
• Expiry date: Aug 30, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the present inventions comprise composites of polyurethane(s), osteoconductive matrix, and, optionally, a growth factor. Embodiments further comprise methods of making such composite and uses thereof. The osteoconductive matrix can be a tricalcium phosphate, bioglass, or the like, and can include particles that are surface modified. Growth factors can be provided in powder form, including bone morphogenic proteins such as rhBMP-2. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells.