Nanoparticles carrying nucleic acid cassettes for expressing RNA
US9801953B2 · kind B2 · utility
3Cited by
2References
4Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 14, 2013 |
| Grant date | Oct 31, 2017 |
| Priority date | — |
| Expiry date | Oct 14, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/1866
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression of siRNAs in vivo using DNA-based siRNA-expressing nanocassettes and receptor-targeted nanoparticles. In certain embodiments, the disclosure relates to methods of targeted delivery of survivin siRNA expressing nanocassettes which enhance sensitivity of human cancer cells to anticancer agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.