Polymer nanoparticle composite and composition for MRI imaging including same

US9801958B2 · kind B2 · utility

Assignee

• THE UNIVERSITY OF TOKYO · JP

Inventors

• Kazunori Kataoka · Bunkyo, JP
• Nobuhiro Nishiyama · Tokyo, JP
• Horacio Cabral · Tokyo, JP
• Peng Mi · Tokyo, JP
• Akihiro Kishimura · Tokyo, JP
• Yutaka Miura · Tokyo, JP
• Ichio Aoki · Chiba, JP
• Daisuke Kokuryo · Chiba, JP
• Tsuneo Saga · Chiba, JP

Key dates

• Filing date: Aug 22, 2014
• Grant date: Oct 31, 2017
• Expiry date: Aug 22, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/1866
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a safe polymer nanoparticle composite with few side effects, and an MRI contrast agent incorporating said polymer nanoparticle composite. The polymer nanoparticle composite is capable of specifically accumulating on a tumor tissue to selectively extract the tissue, exhibiting high contrast even when used in small amounts, and enabling imaging over prolonged periods of time. This polymer nanoparticle composite is characterized by containing a block copolymer that includes a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment, and MnCaP.