Process for the preparation of intermediates useful for the manufacture NEP inhibitors

US9802887B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• David Hook · Rheinfelden, CH
• Bernhard Riss · Huningue, FR
• Jianguang Zhou · 林湖乡, CN
• Yunzhong Li · 安丰镇, CN
• Erhard Bappert · Parma, IT

Key dates

• Filing date: Jun 15, 2015
• Grant date: Oct 31, 2017
• Expiry date: Jun 15, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.