Patent · US Active

Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors

US9802937B2 · kind B2 · utility

7Cited by

4References

26Claims

0Family size

Assignee

Origenis GMBH · DE

Inventors

Michael Thormann · Martinsried, DE
Andreas Treml · Martinsried, DE
Michael Almstetter · Martinsried, DE
Nadine Traube · Martinsried, DE

Key dates

Filing date	Apr 23, 2012
Grant date	Oct 31, 2017
Priority date	—
Expiry date	Oct 17, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D519/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to novel compounds of formula (I)that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.