Heteroaryls and uses thereof

US9802960B2 · kind B2 · utility

Assignee

• Millennium Pharmaceuticals, Inc. · US

Inventors

• Indu T. Bharathan · Somerville, US
• Chris Blackburn · Natick, US
• Jeffrey P. Ciavarri · Reading, US
• Jouhara Chouitar · Stoughton, US
• Courtney A. Cullis · Bedford, US
• Natalie D'Amore · Lynnfield, US
• Paul E. Fleming · Wellesley, US
• Kenneth M. Gigstad · Westford, US
• Krista E. Gipson · Medford, US
• Mario Girard · Quincy, US
• Yongbo Hu · Winchester, US
• Janice Lee · Cambridge, US
• Gang Li · Beijing, CN
• Mansoureh Rezaei · Quincy, US
• Michael D. Sintchak · Winchester, US
• Francois Soucy · Stoneham, US
• Stephen G. Stroud · Medford, US
• Tricia J. Vos · Medford, US
• Tzu-Tshin Wong · Belmont, US
• He Xu · Needham, US
• Tianlin Xu · Shrewsbury, US
• Yingchun Ye · Belmont, US

Key dates

• Filing date: Jan 13, 2015
• Grant date: Oct 31, 2017
• Expiry date: Jan 13, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I:and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.