Patent · US Active

S-adenosylmethionine (SAM) synthase variants for the synthesis of artificial cofactors

US9803180B2 · kind B2 · utility

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1References

6Claims

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Assignee

LEIBNIZ-INSTITUT FÜR PFLANZENBIOCHEMIE STIFTUNG DES ÖFFENTLICHEN RECHTS · DE

Inventors

Martin Dippe · Bodenwerder, DE
Wolfgang Brandt · Halle (Saale), DE
Ludger A. Wessjohann · Bodenwerder, DE
Hannes Rost · Bodenwerder, DE
Andrea Porzel · Bodenwerder, DE

Key dates

Filing date	Sep 4, 2014
Grant date	Oct 31, 2017
Priority date	—
Expiry date	Sep 4, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y205/01006
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to isolated polypeptides that are derived from wildtype Bacillus subtilis S-Adenosylmethionine (SAM) synthase or from a biologically active fragment thereof, wherein said isolated polypeptides comprise an amino acid sequence that, in relation to the amino acid sequence of said wildtype Bacillus subtilis SAM synthase or of the biologically active fragment thereof, comprises at least one amino acid substitution, selected from the group consisting of amino acid substitutions at positions I317 and I105. The present invention further relates to respective isolated nucleic acids, vectors, host cells, uses and methods for the production of SAM derivatives.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.