Method to enable the use of larger injection volumes and to reduce extra-column effects in chromatographic separations
US9804133B1 · kind B1 · utility
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5References
15Claims
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Key dates
| Filing date | Aug 27, 2015 |
| Grant date | Oct 31, 2017 |
| Priority date | — |
| Expiry date | Dec 15, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/085
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus for enabling larger injection volumes and for reducing extra column effects in chromatographic separations using focusing pre-columns placed upstream of the analytical, or preparative, column with applications in any chromatographic system where the requirement is that the focusing pre-column, placed upstream of the analytical column, allows larger injection volumes to be utilized and, by enabling efficient focusing of solutes onto the analytical column, results in a significant reduction of band broadening due to extra-column effects which act upstream of the analytical column.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.