Pharmaceutical compounds and use of same in cancer and tauopathies
US9808448B2 · kind B2 · utility
2Cited by
2References
18Claims
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Key dates
| Filing date | Apr 11, 2017 |
| Grant date | Nov 7, 2017 |
| Priority date | — |
| Expiry date | Apr 11, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are compounds of formula (l)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease (AD). The presence of abnormal tau correlates with neuron loss and memory deficits in patients with AD and other neurodegenerative disorders that involve tau accumulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.