Unit structure-type pharmaceutical composition for nucleic acid delivery

US9808480B2 · kind B2 · utility

Assignees

• NANOCARRIER CO., LTD. · JP
• THE UNIVERSITY OF TOKYO · JP

Inventors

• Kazunori Kataoka · Bunkyo, JP
• Kanjiro Miyata · Tokyo, JP
• Nobuhiro Nishiyama · Tokyo, JP
• Kensuke Osada · Tokyo, JP
• Sumiyo Watanabe · Tokyo, JP
• Shigeto Fukushima · Narashino, JP
• Hiroyuki Chaya · Tokyo, JP
• Hiroyasu Takemoto · Tokyo, JP
• Yasuki Kato · Kashiwa, JP

Key dates

• Filing date: Apr 30, 2013
• Grant date: Nov 7, 2017
• Expiry date: Apr 30, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K48/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A unit structure-type pharmaceutical composition includes at least one nucleic acid, such as siRNA, electrostatically bound to at least one block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. The negative charge(s) of the nucleic acid are counterbalanced, at least substantially, by the positive charge(s) of the cationic polyamino acid segment such that the pharmaceutical composition is electrically neutral or nearly electrically neutral. Further, the nucleic acid is covered with the hydrophilic polymer chain segment(s). The at least one block copolymer thereby improves the blood retention capability of the nucleic acid(s).