Protein-polymer-drug conjugates and methods of using same

US9808528B2 · kind B2 · utility

Assignee

• Mersana Therapeutics, Inc. · US

Inventors

• Natalya D. Bodyak · Boston, US
• Timothy B. Lowinger · Carlisle, US
• Peter U. Park · Lexington, US
• Aleksandr V. Yurkovetskiy · Littleton, US

Key dates

• Filing date: Jun 18, 2015
• Grant date: Nov 7, 2017
• Expiry date: Jun 18, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders, such as cancer in a subject having low HER2 expression with the conjugates or their compositions are also described.