Peptides whose uptake in cells is controllable

US9808532B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Roger Y. Tsien · Village of La Jolla, US
• Emilia Olson · Seattle, US
• Tao Jiang · San Diego, US
• Quyen Nguyen · Beltsville, US
• Michael Whitney · Village of La Jolla, US

Key dates

• Filing date: Jul 15, 2010
• Grant date: Nov 7, 2017
• Expiry date: Jun 15, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)n-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutatmates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.