Regenerative peripheral nerve interface

US9808616B2 · kind B2 · utility

Assignees

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US
• University Of Delaware · US

Inventors

• Paul S. Cederna · Grass Lake, US
• Melanie G. Urbanchek · Ann Arbor, US
• David C. Martin · Worthington, US

Key dates

• Filing date: Jan 13, 2012
• Grant date: Nov 7, 2017
• Expiry date: May 24, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/32
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present disclosure provides a regenerative peripheral nerve interface (RPNI) for a subject comprising an insulating substrate, at least one metallic electrode deposited onto the insulating substrate forming a thin-film array; a portion of the at least one metallic electrode surface having a layer of a first conductive polymer and a layer of decellularized small intestinal submucosa (SIS) coating a portion of the electrode, wherein a second conductive polymer is electrochemically polymerized through the SIS to form the regenerative peripheral nerve interface. The present disclosure also provides that a layer of muscle tissue contacts the regenerative peripheral nerve interface.