Patent · US Active

Genetically modified host cells and use of same for producing isoprenoid compounds

US9809829B2 · kind B2 · utility

7Cited by

10References

30Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Jay D. Keasling · Berkeley, US
James Kirby · Berkeley, US
Eric M. Paradise · Vienna, US

Key dates

Filing date	Aug 4, 2014
Grant date	Nov 7, 2017
Priority date	—
Expiry date	Nov 10, 2034

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.