Methods for the treatment of depression and anxiety

US9814755B2 · kind B2 · utility

Assignee

• Arizona Board of Regents on Behalf of the University of Arizona · US

Inventors

• Victor J. Hruby · Tucson, US
• Minying Cai · Tucson, US
• Horst Kessler · Schwalbach, DE

Key dates

• Filing date: Nov 17, 2015
• Grant date: Nov 14, 2017
• Expiry date: Nov 17, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/7023
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of treating a depressive disorder or an anxiety disorder in a subject in need of such treatment are described. A therapeutically effective amount of a composition comprising Ac-Nle4-c[Asp5-His6-(NMe)D-Nal(2′)7-Arg8-Trp9-(NMe)Lys10]-NH2 (PEPTIDE 9), in a pharmaceutically acceptable carrier is administered to the subject. PEPTIDE 9 is a selective MC5R antagonist, in which administration thereof to the subject can treat the depressive or generalized anxiety disorder with clinical improvement observed in a relatively short time.