Inhibitors of apoptosis and uses thereof

US9814758B2 · kind B2 · utility

Assignees

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES · FR
• Universite De Montpellier · FR

Inventors

• Stéphanie Barrere · Vendémian, FR
• Joël Nargeot · Montpellier, FR
• Bernard Lebleu · Montpellier, FR
• Prisca Boisguerin · St-Estève, FR
• Christophe Piot · Tournon-sur-Rhône, FR

Key dates

• Filing date: Nov 17, 2011
• Grant date: Nov 14, 2017
• Expiry date: Nov 19, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/4747
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to fragments of the Death-Domain Associated protein (DAXX protein) and of the Fas-Associated Death Domain protein (FADD protein) that inhibit cell apoptosis, in particular cell apoptosis mediated by the Fas receptor. The invention also relates to derivatives of said anti-apoptotic fragments, conjugates comprising said fragments, pharmaceutical compositions comprising said fragments, and to the medical applications of said fragments, derivatives, conjugates, and pharmaceutical compositions thereof in the treatment or prevention of diseases and conditions associated with apoptosis.