One component fibrin glue comprising zymogens

US9814765B2 · kind B2 · utility

Assignees

• Ethicon, Inc. · US
• Omrix Biopharmaceuticals Ltd. · IL

Inventors

• Yair Pilpel · Rehovot, IL
• Ashley DeAnglis · Skillman, US
• Yuri Zherdev · Rehovot, IL
• Sivan Doron · Arugot, IL
• Anne Gorman · Hightstown, US
• Israel Nur · Afula, IL

Key dates

• Filing date: Dec 4, 2014
• Grant date: Nov 14, 2017
• Expiry date: Jan 16, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y304/21021
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is a single component sealant formulation (e.g. in a liquid form), methods for its preparation, and use. The formulation includes fibrinogen; vitamin K-dependent clotting zymogens comprising at least Factor II (FII) and Factor X (FX).