Patent · US Active

Method for obtaining antigen-specific human antibodies by in vitro immunisation

US9816072B2 · kind B2 · utility

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14Claims

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Assignee

COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · FR

Inventors

Michel Leonetti · Nozay, FR
Patricia Lamourette · Gif-sur-Yvette, FR
Herve Volland · Orsay, FR
Alexandra Savatier · Étampes, FR
Anne WIJKHUISEN · Étampes, FR

Key dates

Filing date	Nov 26, 2013
Grant date	Nov 14, 2017
Priority date	—
Expiry date	Nov 26, 2033

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/575
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method for the in vitro immunization of human B lymphocytes, comprising culturing a total mononuclear cell population of human peripheral blood in the presence of an antigenic composition comprising at least one antigen covalently bonded to both: (i) a Tat protein or a Tat fragment capable of oligomerization and (ii) a ligand of a surface molecule specific to the antigen presenting cells; a method for producing antigen-specific human antibodies derived from said in vitro immunization method.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.