Chemical modification of short small hairpin RNAs for inhibition of gene expression
US9816091B2 · kind B2 · utility
1Cited by
7References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 3, 2014 |
| Grant date | Nov 14, 2017 |
| Priority date | — |
| Expiry date | Oct 3, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/53
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Aspects of the present invention include the production and use of chemically modified RNAi agents (e.g., shRNAs) in gene silencing applications. The chemically modified RNAi agents disclosed herein have reduced immunostimulatory activity, increased serum stability, or both, as compared to a corresponding RNAi agent not having the chemical modification. Compositions containing chemically modified RNAi agents according to aspects of the present invention (including pharmaceutical compositions) and kits containing the same are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.