Method for selection of agents influencing intestinal motility disorders and pain
US9816150B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 23, 2016 |
| Grant date | Nov 14, 2017 |
| Priority date | — |
| Expiry date | Dec 23, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30092
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, comprising: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyze the effect of the agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyze the effect of the agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of the bacterial strains in the treatment of intestinal motility disorders are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.