Multi-photon microscope having an excitation-beam array

US9820652B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Tong Zhang · Palo Alto, US
• Mark J. Schnitzer · Summit, US
• Jerome Anthony-Jean Lecoq · East Palo Alto, US
• Joan Savall · Palo Alto, US
• Hyun Eui KIM · Cheongju-si, KR
• Oleg Rumyantsev · Stanford, US

Key dates

• Filing date: Dec 8, 2014
• Grant date: Nov 21, 2017
• Expiry date: Jan 1, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/0042
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A two-photon imaging system capable of imaging of an image region in real time is presented. The imaging system comprises a source of excitation light that provides the excitation light as a plurality of laser beamlets. The plurality of laser beamlets is collectively scanned by a single-axis scanner along a first direction in the focal plane of the image region and oriented such that neither the rows nor columns are aligned with the first direction. As a result, each laser beamlet scans a different sub-region of the image region and the plurality of sub-regions are simultaneously scanned. As a result, the entirety of the image region is scanned in the same amount of time required to scan one image sub-region.