Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof

US9822126B1 · kind B1 · utility

Assignee

• COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH · IN

Inventors

• Kushalava Reddy YEMPALLA · Jammu, IN
• Gurunadham MUNAGALA · Jammu, IN
• Samsher Singh · Jammu, IN
• Sumit SHARMA · Tashidongze, IN
• Inshad Ali Khan · Jammu, IN
• Ram Vishwakarma · Jammu, IN
• Parvinder Pal Singh · Jammu, IN

Key dates

• Filing date: Sep 16, 2015
• Grant date: Nov 21, 2017
• Expiry date: Sep 16, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to new generation of triazole functionality containing 6-nitro-2,3-dihydroimidazooxazole agents for general formula I, their method of preparation and their use as drugs for treatment of tuberculosis, MDR-TB and XDR-TB either alone or in combination with other anti-tubercular agents. In general formula 1, X is selected from a group (CH2)n or a direct bond, where n is any number from 1-6, Y is selected from O, S or direct bond, R1 is selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, biaryl, substituted biaryl, heterocyclic and substituted heterocyclic, wherein the substituted heterocyclic is selected from any of the following rings consisting of piperazinyl, morpholinyl, piperidyl, pyridyl, triazolyl, triazinyl, pyrimidinyl, pyridazinyl, oxazolyl, furanyl, benzofuranyl, thiophenyl, pyrrolyl, imidazoyl, thiazoyl, quinolinyl, isoquinolinyl, benzooxazolyl and benzothiazolyl and the substitution on aryl and biaryl is selected from the group consisting of F, CI, Br, I, CF3, OCF3, OR11, NO2 and alkyl chain from C1 to C14, wherein R11 is selected from the group consisting of H, alkyl, phenyl and substituted phenyl.