Methods of making carfilzomib and intermediates thereof

US9822145B2 · kind B2 · utility

Assignee

• Apicore US LLC · US

Inventors

• Ravishanker Kovi · Sparta, US
• Jayaraman Kannapan · Sayla, IN
• Vasanthakumar G Ramu · Savanuru, IN
• Alaparthi Lakshmi Prasad · Vadodara, IN
• Talluri Bhushaiah Chowdary · Tenali, IN
• Gaurav Kulkarni · Sayla, IN
• Saiyed Akeel Ahmed Shakeel Ahmed · Vadodara, IN
• Veerabhadra Rao Bobbili · Darsi, IN
• N V Raghavalu Dusanapudi · Darsi, IN
• Anand V. Mantri · Vadodara, IN

Key dates

• Filing date: Aug 4, 2016
• Grant date: Nov 21, 2017
• Expiry date: Aug 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06078
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Racemization-free methods are disclosed for the synthesis of carfilzomib. Novel intermediates and methods of making carfilzomib employing fragment condensation using the novel intermediates are disclosed. Amorphous carfilzomib and methods of making same are disclosed.