High affinity NY-ESO T cell receptors
US9822163B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Oct 12, 2016 |
| Grant date | Nov 21, 2017 |
| Priority date | — |
| Expiry date | Oct 12, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.