Compositions and methods for treating lung disease and injury

US9822362B2 · kind B2 · utility

Assignees

• QUARK PHARMACEUTICALS, INC. · US
• Washington University · US

Inventors

• Andrew E. Gelman · Los Angeles, US
• Elena Feinstein · Rehovot, IL
• Svetlana Adamsky · Gdera, IL
• Igor Mett · Rehovot, IL
• Hagar Kalinski · Nesher, IL
• Sharon Avkin-Nachum · Nes Ziona, IL

Key dates

• Filing date: Oct 28, 2015
• Grant date: Nov 21, 2017
• Expiry date: Oct 28, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/344
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising down-regulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.