Intracellular translation of circular RNA
US9822378B2 · kind B2 · utility
7Cited by
8References
17Claims
0Family size
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Inventor
Key dates
| Filing date | May 13, 2014 |
| Grant date | Nov 21, 2017 |
| Priority date | — |
| Expiry date | May 13, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2999/007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely long half-life inside cells. This circular mRNA is functional inside mammalian cells, being able to compete against native cellular mRNAs for the eukaryotic translation initiation machinery. The invention possesses additional RNA elements compared to a previous invention containing only an IRES element for successful in vitro or in vivo translation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.